Bioactive Small Molecules
Medchemexpress LLC TROP-2 Cynomolgus 500ug | 500ug
The TROP-2 protein emerged as a potential growth factor receptor implying involvement in cellular processes related to growth and signaling As a putative receptor TROP-2 may play a crucial role in transducing signals that regulate cell growth and proliferation TROP-2 Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived TROP-2 protein expressed by HEK293 with C-His labeled tag
Cayman Chemical ANTIBODY CUDC-101 50mg
A multi-target inhibitor that potently blocks EGFR and HER2 (IC50s = 2.4 and 16.4 nM, respectively) and inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC50s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively)
![Medchemexpress LLC 1H-pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- | 1679333-73-3 | 98.5% | 361.22 g/mol | C18H14Cl2N2O2 | 10MM 1ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237658.png-250.jpg)
Medchemexpress LLC 1H-pyrido[3,4-b]indole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-, (1R,3S)- | 1679333-73-3 | 98.5% | 361.22 g/mol | C18H14Cl2N2O2 | 10MM 1ML
MMV008138 is a small-molecule IspD inhibitor used in antimalarial research and biochemical screening. The compound is provided in both solid form and a ready-to-use 10 mM solution in DMSO, with confirmed molecular formula C18H14Cl2N2O2, molecular weight 361.22 g/mol, and high purity suitable for assay work. Certificate of analysis and product datasheet are available for quality verification.
- Species-selective IspD inhibitor for antimalarial studies.
- High purity suitable for biochemical and cellular assays.
- Available as solid or 10 mM solution in DMSO for convenience.
- Molecular weight 361.22 g/mol and formula C18H14Cl2N2O2.
- Certificate of analysis available for batch verification.
Cayman Chemical ANTIBODY WAY-600 10mg
An mTOR inhibitor (IC50 = 0.009 µM); selectively inhibits mTOR over PI3Kα and PI3Kɣ (IC50s = 1.96 and 8.45 µM, respectively) and 24 additional lipid and protein kinases in a panel (IC50s = >50 µM for all); decreases phosphorylation of Akt and S6K1 in a cell-free assay at 0.2, 1, and 5 µM; decreases proliferation of nine cancer cell lines, including breast, prostate, glioma, kidney, and colorectal cancer cells (IC50s = 0.6-2.5 µM); reduces tumor growth in a HepG2 mouse xenograft model at 10 mg/kg for 14 days
Selleck Chemical LLC Sodium propionate E4022-1G
Sodium propionate (sodium propanoate) a short chain fatty acid is a white crystalline salt derived from propionic acid with anti-inflammatory properties Sodium propionate is used as a supplement in transgalactic-oligosaccharides (TOS) medium for the isolation of bifidobacteria and as a supplement in the SCFA (short-chain fatty acid) diet prepared for mice
Medchemexpress LLC HY-19992 500mg , 3-Bromopyruvic acid CAS:1113-59-3 Purity:>98%
HY-19992 500mg 3-Bromopyruvic acid CAS: 1113-59-3 3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Abcam STF-083010, IRE1alpha endonuclease inhibitor, 25MG
MW 317.4 Da. Selective IRE1α endonuclease inhibitor. Dose dependently inhibits XBP-1 splicing. Shows cancer cell selective cytotoxic and cytostatic antiproliferative effects. Shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ANTIBODY ArbutIn 10g
A glycosylated hydroquinone with diverse biological activities; inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM); inhibits AAPH-induced hemolysis in sheep erythrocytes at 50 μM; inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts at >125 μM; prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum in an LPS-induced rat model of acute lung injury at 50 mg/kg
Cayman Chemical SemaglutIdeacetate 5mg
A GLP-1R agonist (EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor); decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = <2 nmol/kg); prevents decreases in the number of dopaminergic neurons in the substantia nigra and increases in lipid peroxidation in the substantia nigra and striatum, as well as improves motor coordination in the rotarod and footprint tests in a mouse model of Parkinson’s disease induced by MPTP at 25 nmol/kg; decreases neuronal loss in the hippocampal dentate gyrus and CA1 and CA3 regions and improves motor coordination and grip strength in the beam-walking and hanging wire tests, respectively, in a rat model of stroke induced by permanent MCAO at 10 nmol/kg every other day
Cayman Chemical ANTIBODY-Baclofen 25g
A GABAB receptor agonist (IC50 = 180 nM); induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM); increases muscle rigidity in spastic mice at 10 mg/kg; inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats; reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice
Selleck Chemical LLC 5-amiloride E7765-5MG
5-(N N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na /H exchanger inhibitor which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells 5-(N N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3 91 M and 1 34 M respectively
AdipoGen Ponatinib
Chemical. CAS 943319-70-8. Formula C29H27F3N6O. MW 532.6. Soluble in DMSO 30mg/ml, DMF 30mg/ml or ethanol 5mg/ml. Ponatinib is a potent multi-target kinase inhibitor with antiangiogenic and antineoplastic activities. It targets protein tyrosine kinases PTK, which catalyze the transfer of ATP-γ-phosphate to the tyrosine residues of the substrate proteins. Tyrosine kinase inhibitors TKIs compete with ATP for the ATP binding site of PTK and reduce tyrosine kinase phosphorylation, thereby inhibiting cancer cell proliferation. Ponatinib is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor of native BCR-ABL IC50 = 0.37nM, the tyrosine kinase inhibitor-resistant mutant Bcr-AblT315I IC50 = 2nM, as well as Bcr-AblQ252H, Bcr-AblY253F, Bcr-AblM351T and Bcr-AblH396P mutants IC50s = 0.44, 0.3, 0.3, and 0.34nM, respectively in biochemical assays.
Cayman Chemical PInaverIumbromIde 5mg
An L-type calcium channel inhibitor (IC50 = 1.5 µM in a patch-clamp assay using isolated rabbit jejunal smooth muscle cells); binds to CHO cells expressing the Cav1.2 α1C-a or α1C-b subunits (Kis = 1.5 and 2.92 µM, respectively); inhibits ACh- or potassium chloride-induced contractions in colonic circular muscle strips isolated from non-stressed or cold-restraint-stressed rats (IC50s = 0.91 and 1.66 µM for ACh, respectively, and 3.8 and 8.13 µM for potassium chloride, respectively) in a model of stress-induced smooth muscle contractility disorder; increases survival and decreases pulmonary neutrophil infiltration in a mouse model of LPS-induced septic shock from 1-10 mg/kg
STEMCELL Technologies Z-VAD-FMK, Size: 5 mg
Z-VAD-FMK is a cell-permeable synthetic peptide that inhibits caspases and blocks caspase-mediated apoptosis in vivo (Garcia-Calvo et al.; Xiang et al.). Z-VAD-FMK prevents differentiation and enhances the freeze-thaw survival rate of human embryonic stem cells when subjected to cryopreservation conditions (Heng et al.).CANCER RESEARCH· Blocks Fas-induced apoptosis in T lymphocytes (Chow et al.).
TARGETMOL CHEMICALS INC TAK-960 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. TAK-960 is an orally bioavailable selective inhibitor of Plks with IC50 values of 0.8 16.9 and 50.2 nM for Plk1 Plk2 and Plk3 respectively. purity: 98%